Headline, March 21 2019/ ''' '' HOPE -HYPER- HOUR '' ''' : WINNINGS

''' '' HOPE -HYPER- HOUR '' ''' : WINNINGS

DR KEVAN SHOKAT, A CHEMIST at the University of California, San Francisco, is poring through 20,000 drugs approved by the-

The Food and Drug Administration for signs that they may interact with the proteins on the map created by Dr. Kogan's lab.

Dr.Shokat and his colleagues have found 50 promising candidates. The protein BRD2, for example, can be targeted by a drug called JQI. Researchers originally discovered JQI as a potential treatment for several types of cancer.

Last week, Dr. Shokat and his colleagues filled a box with the first 10 drugs on the list and shipped them overnight to New York to be tested against the living coronavirus.

The drugs arrived at the lab of Aolofo Garcia-Sastre, director of Global Health and Emerging Pathogens Institute at Mount Sinai Hospital. Dr. Garcia-Sastre recently began growing the coronavirus in monkey cells.

Over the weekend, the team at the institute began treating infected cells with the drugs to see if any stop the viruses. ''We have started experiments, but it will take us a week to get the first data here,''  Dr Garcia-Sastre said on Tuesday.

The researchers in San Francisco also sent the batch of drugs to the Pasteur Institute in Paris, where investigators also have begun testing them against the coronaviruses.

If promising drugs are found, investigators plan to try them in an animal infected with the coronavirus.

SOME RESEARCHERS AT THE Quantitative Biosciences Institute began studying the coronavirus in January.

But last month, the threat became more imminent : A woman in California was found to be infected although she had not recently traveled outside the country.

The finding suggested that the virus was already circulating in the community.

''I got to the lab and said we've got to drop everything else,'' recalled Nevan Krogan, director of the  Quantitative Biosciences Institute. ''Everybody has to work round the clock on this.''

Dr. Krogan and his colleagues set about finding proteins in our cells that the coronavirus uses to grow. Normally, such a project might take two years. But the working group, which includes 22 laboratories, completed it in a few weeks.

WORKING AT A BREAKNECK PACE, A TEAM OF hundreds of scientists has identified 50 drugs that may be effective treatments for people infected with the coronavirus.

Many scientists are seeking drugs that attack the virus itself. But, the team, the Quantitative Biosciences Institute Coronavirus Research Group, based at the University of California, San Francisco, is testing an unusual approach.

The researchers are looking for drugs that shield proteins in our own cells that the coronavirus depends on to thrive and reproduce.

Collaboration of every kind is in full swing to find an antiviral drug that effective against coronavirus. One of the most closely watched efforts involves an antiviral called remdesivir.

In past studies on animals, remdesivir blocked a number of viruses. The drug works by preventing viruses from building new genes.

In February, researchers found that remdesivir could eliminate the the coronavirus from infected cells. Since then, five clinical trials have begun to see if the drug will be safe and effective against Covid-19 in people. 

Other researchers have taken startling new approaches. On Saturday, Stanford university researchers reported using the gene-code editing technology Crispr, to destroy coronavirus genes in infected cells.

As the Bay area went into lockdown on Monday, Dr. Krogan and his colleagues were finishing their map. They are preparing a report to post online by the end of the week, while also submitting it to a journal for publication.

The Honor and Serving of the Latest Global Operational Research on Coronavirus and Treatment options, continues. The World Students Society thanks author Carl Zimmer.

With respectful dedication to the Scientists, Researchers, Chemists, Students, Professors and Teachers of the world. See Ya all prepare and register for Great Global Elections on The World Students Society: wssciw.blogspot.com and Twitter - !E-WOW! - The Ecosystem 2011:

''' Matter - Master '''

Good Night and God Bless

SAM Daily Times - the Voice of the Voiceless


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